On the intensity of the accelerating action of eserine upon the epinephrine secretion of the suprarenal gland.

(From the Physiological Laboratory of Prof. Y. Satake, Tohoku University, Sendai.) (Received for publication, August 9, 1949) In the studies on the effect of eserine upon the augmented epinephrine secretion caused by KCl in non-anesthetized dogs, which were performed by the present writer in collaboration with Matumoto, Sasaki and Nuno kawa,1) we noticed that the epinephrine secretion rate from the suprarenal gland remained almost unaltered after intravenous injection of eserine in a dose of 0.3mg. per kg. of body weight, in spite of the occurrence of serious symptoms of eserine poisoning. F. Watanabe2) in this laboratory reported also some years ago on the action of eserine upon the epinephrine secretion from the suprarenal gland in non-anesthetized dogs. In his experiments eserine was injected sub cutaneously in a dose of 1.0mg., 0.5mg. and 0.25mg. per kg. Only a very slight acceleration of epinephrine secretion was observed. 0.08ƒÁ per kg. per minute from one gland was the maximal value of accelerated epine